Supplements Checklist
Supplements are important to optimize longevity and health.
My supplement stack which is well-optimized for longevity, exercise recovery, and sleep. It also considers cross-effects between the various supplements. I try to limit the number of supplements to only scientifically proven to be effective.
π Morning (Energy, Longevity, Metabolism):β
- Niagen (Nicotinamide Riboside) 300 - 500 mg + TMG (500 mg), supports cellular health boosts NAD+ levels and may enhance energy production.
- Vitamin D3 3,000 - 5,000 IU + K2 100mcg, essential for immune health, bone density, and cardiovascular function. K2 ensures proper calcium distribution (keeps it in bones, not arteries). Ensure you monitor blood levels of Vitamin D (25(OH)D) at least once a year.
- Collagen, 10-15 g + Vitamin C (~500 mg), supports healthy hair, nails, and skin. Vitamin C enhances collagen synthesis.
- Magnesium (complex or bioavailable form like citrate, glycinate, malate), 400 - 500+ mg, supports muscle and nerve function, splitting doses across the day is better for absorption.
- Resveratrol (100-500 mg) + Omega-3 (1-2 g EPA/DHA)
- Urolithin A (250-500 mg) + PQQ (10 mg)
- Alpha-Ketoglutarate (1-2 g) + Magnesium (200 mg)
- Spermidine (5-10 mg) + Fisetin (100-400 mg, once weekly)
π₯ Lunch (Metabolic Health, Muscle Retention):β
- Lutein & Zeaxanthin: 20 mg, 4 mg, combined with fat meal for better absorption for eye health.
- Creatine (micronized): 3 - 5 g, Supports brain function, muscle retention, and ATP production. New research suggests it protects cognitive function and enhances longevity pathways.
- Zinc Orotate: 15 mg + Copper 1-2 mg, every other day), Supports immune system, testosterone levels, and sperm count. Higher dose can deplete copper levels. If taking long-term, add copper (1-2 mg) to avoid deficiency.
- Omega-3 (1 - 2g DHA/EPA per day) for longevity & anti-inflammatory effects.
- Protein 30mg (extra if skipping meals)
- Berberine (500 mg, before meal)
Evening:β
- Inulin (3-5 g daily) strong prebiotic effect
- Magnesium Glycinate (300 mg) β A highly bioavailable form of magnesium that relaxes muscles, reduces stress, and improves sleep quality by regulating GABA activity.
- L-Theanine (200 mg) β An amino acid found in green tea that promotes relaxation without drowsiness, enhances alpha brain waves, and reduces cortisol levels.
- Glycine (3 g) β Works synergistically to enhance sleep efficiency, lower body temperature for sleep onset, and support collagen synthesis for muscle repair. Glycine also supports collagen and cognitive function.
- Melatonin (0.5β1 mg) β Supports circadian rhythm regulation, especially useful for jet lag, night shifts, or inconsistent sleep schedules.
- Ashwagandha (300 mg) β An adaptogen that reduces cortisol levels by up to 30%, enhances stress resilience, and supports testosterone and thyroid function.
Power Shake during daytime:β
- Protein (whey or plant-based): 30 g
- Spirulina: 5 g
- Chlorella: 5 g
- Moringa: 3 g
Change Log:
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TMG (Trimethylglycine, 500β1000 mg) β Supports methylation if taking NR long-term.
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Vitamin C (500 mg) β Enhances collagen absorption and immune health.
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Copper (1-2 mg) β If taking zinc long-term to prevent deficiency.
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Taurine (1 g) β Synergistic with magnesium, promotes cardiovascular & nervous system health.
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Berberine (500 mg, before meals) β Supports blood sugar regulation and mimics some metformin-like longevity benefits.
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Reduce Lutein (44 mg) & Zeaxanthin (11 mg) β Lutein (20 mg) & Zeaxanthin (4 mg)
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Keep only one zinc dose (15 mg per day) + add 1-2 mg copper
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Increase Omega-3 (EPA/DHA) to 1-2 g/day if not eating fish
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Consider adding TMG (500 mg) if continuing NR long-term
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Add Vitamin C (500 mg) with Collagen for better absorption
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Increase Inulin (3-5 g) for stronger gut microbiome support
Supplements I'm currently experimenting with:β
Based on the latest scientific evidence on longevity, cognitive function, metabolic health, and athletic performance, here are some high-impact supplements that I consider adding:
Your current stack is already quite comprehensive, but based on the latest scientific evidence on longevity, cognitive function, metabolic health, and athletic performance, here are some high-impact supplements that you might want to consider adding:
- Fisetin (100β400 mg, 1-2x/week) β Senolytic & Longevity
β Why? β’ One of the most potent senolytics (clears out senescent βzombieβ cells that accelerate aging and inflammation). β’ Supports cognitive function, reduces inflammation, and extends lifespan in animal models. β’ Works synergistically with NR (Nicotinamide Riboside) to improve cellular function.
β Best time: β’ Take 100β400 mg once or twice per week with fat for better absorption (e.g., with lunch). β’ Cycling (e.g., one week per month) may be optimal for long-term use.
- Spermidine (5-10 mg/day) β Autophagy & Longevity
β Why? β’ Promotes autophagy (cellular cleanup & recycling)βa key longevity pathway. β’ Improves cardiovascular health, immune function, and mitochondrial efficiency. β’ Strong anti-aging effects seen in human epidemiological studies.
β Best time: β’ Take 5-10 mg with food (often found in wheat germ extract). β’ Works well with NR and resveratrol for longevity.
- Berberine (500 mg, 2x/day) β Metabolic Health & Longevity
β Why? β’ Mimics Metformin (activates AMPK, lowers blood sugar, improves insulin sensitivity). β’ Improves lipid profile, lowers inflammation, and may protect against neurodegeneration. β’ Synergistic with Omega-3 and NR for metabolic health.
β Best time: β’ 500 mg before meals (2x per day, e.g., lunch & dinner) for optimal blood sugar control. β’ If experiencing mild GI upset, reduce to once daily.
- Urolithin A (250-500 mg/day) β Mitochondrial Function & Muscle Endurance
β Why? β’ Derived from ellagitannins (in pomegranates), but in amounts impossible to get from food. β’ Boosts mitochondrial function, improves muscle endurance, and increases longevity in animal models. β’ Shown to improve muscle function in aging adults.
β Best time: β’ Morning, with or without food. β’ Works synergistically with creatine, NR, and Omega-3s.
- Taurine (1-2 g/day) β Longevity & Heart Health
β Why? β’ One of the strongest longevity-promoting supplements in animal models. β’ Supports cardiovascular function, mitochondrial health, and stress resilience. β’ Improves sleep quality, exercise recovery, and electrolyte balance. β’ Works synergistically with magnesium, creatine, and glycine.
β Best time: β’ Evening (improves sleep) or pre-workout (improves exercise performance & endurance). β’ Works well with L-Theanine and Glycine at night for calming effects.
- Lithium Orotate (5 mg/day) β Brain Health & Neuroprotection
β Why? β’ Neuroprotective, anti-inflammatory, and mood-stabilizing effects. β’ Reduces neurodegeneration risk (Alzheimerβs, Parkinsonβs, etc.). β’ Supports cognitive longevity and stress resilience.
β Best time: β’ Evening, with magnesium & glycine (calming effect). β’ Dose: 5 mg/day (not the high pharmaceutical doses used for psychiatric conditions).
- Alpha-Ketoglutarate (AKG, 1-2 g/day) β Aging & Mitochondrial Health
β Why? β’ Extends lifespan in mice by 20-40% via metabolic optimization. β’ Enhances mitochondrial function, muscle performance, and cellular energy production. β’ Strong synergy with NR (Nicotinamide Riboside) and Urolithin A for longevity.
β Best time: β’ Morning (on an empty stomach or with NR). β’ Dose: 1-2 g per day.
- Resveratrol (100-500 mg/day) β SIRT1 Activation & Longevity
β Why? β’ Activates SIRT1 (a longevity gene). β’ Works synergistically with NR to enhance NAD+ function. β’ Improves insulin sensitivity, cardiovascular health, and reduces inflammation.
β Best time: β’ Morning with food (fat improves absorption). β’ Pair with NR and Omega-3 for a powerful anti-aging stack.
- Apigenin (50 mg/day) β Sleep & Cellular Health
β Why? β’ Reduces cortisol & enhances sleep quality (via GABA activation). β’ Inhibits CD38, which depletes NAD+ (synergistic with NR). β’ Supports brain function & reduces oxidative stress.
β Best time: β’ Before sleep (with L-Theanine & Glycine for enhanced relaxation).
- PQQ (10-20 mg/day) β Mitochondrial Biogenesis
β Why? β’ Increases mitochondrial biogenesis & function. β’ Protects against oxidative stress and cognitive decline. β’ Works well with Urolithin A, AKG, and Taurine for energy & cellular health.
β Best time: β’ Morning (with NR and Urolithin A for mitochondrial synergy).
Final Optimized Plan
π Morning (Energy, Longevity, Metabolism): β’ Niagen (NR) (300 mg) + TMG (500 mg) β’ Vitamin D3 (5,000 IU) + K2 (100 mcg) β’ Resveratrol (100-500 mg) + Omega-3 (1-2 g EPA/DHA) β’ Urolithin A (250-500 mg) + PQQ (10 mg) β’ Alpha-Ketoglutarate (1-2 g) + Magnesium (200 mg) β’ Spermidine (5-10 mg) + Fisetin (100-400 mg, once weekly)
π₯ Lunch (Metabolic Health, Muscle Retention): β’ Creatine (3-5 g) β’ Protein (30 g) β’ Berberine (500 mg, before meal) β’ Zinc (15 mg) + Copper (1-2 mg, every other day)
π Before Bed (Recovery, Relaxation, Neuroprotection): β’ Magnesium Glycinate (300 mg) + Taurine (1 g) β’ L-Theanine (200 mg) + Apigenin (50 mg) β’ Glycine (3 g) + Melatonin (0.5 mg) β’ Ashwagandha (300 mg) + Lithium Orotate (5 mg)
Key Takeaways
β You have an excellent base (NR, Omega-3, Magnesium, Creatine, Collagen, Ashwagandha). β Highly recommended additions for longevity: Fisetin, Spermidine, Urolithin A, Berberine, AKG, PQQ. β For cognitive protection: Taurine, Lithium Orotate, Apigenin. β For mitochondrial function: Alpha-Ketoglutarate, PQQ, Urolithin A.
This optimizes your stack for exercise recovery, metabolic health, mitochondrial efficiency, and longevity based on the latest scientific research. π Let me know if you need adjustments!